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Monday, April 27, 2020 | History

5 edition of Nucleoside Mimetics found in the catalog.

Nucleoside Mimetics

Their Chemistry and Biological Properties (Advanced Chemistry Texts)

by Claire Simons

  • 388 Want to read
  • 35 Currently reading

Published by CRC .
Written in English

    Subjects:
  • Pharmacology,
  • Polymer chemistry,
  • Science,
  • Nucleic Acids,
  • Organic Chemistry,
  • Business / Economics / Finance,
  • Science/Mathematics,
  • General,
  • Science / Biochemistry,
  • Chemistry - Organic,
  • Life Sciences - Biochemistry

  • The Physical Object
    FormatHardcover
    Number of Pages200
    ID Numbers
    Open LibraryOL9106643M
    ISBN 109056993240
    ISBN 109789056993245


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Nucleoside Mimetics by Claire Simons Download PDF EPUB FB2

Nucleoside Mimetics provides an introduction to the chemistry of nucleoside mimetics, which combines carbohydrate, heterocyclic and asymmetric synthesis. The book gives a comprehensive introduction to nucleosides and coverage of the various classes.

The aim of Nucleoside Mimetics is to provide the reader with Nucleoside Mimetics book useful insight into the diversity Cited Nucleoside Mimetics book The book gives a comprehensive introduction to nucleosides and coverage of the various classes.

The aim of Nucleoside Mimetics is to provide the reader with a useful insight into Nucleoside Mimetics book diversity of nucleosides, the Nucleoside Mimetics book of elegant chemistry involved and the continuing importance of nucleosides as both therapeutic agents and as probes for.

The book gives a comprehensive introduction to nucleosides and coverage of Nucleoside Mimetics book various classes. The aim of Nucleoside Mimetics Nucleoside Mimetics book to provide the reader with a useful insight into the diversity of nucleosides, the range of elegant chemistry involved and the continuing importance of nucleosides as both therapeutic agents and as probes for Author: Claire Simons.

Abstract. Modified nucleosides are useful therapeutic agents being currently used as antitumor, antiviral, and antibiotic agents. Despite the fact that a significant variety of modified nucleosides display potent and selective action against cancer, viral and microbial diseases, the challenge still attracts full attention since most of them do not discriminate between normal and tumor cell and.

Nucleosides exhibit a broad spectrum of biological activity that generally results from their ability to inhibit specific enzymes. This activity has led to their use in the development of various pharmaceutical agents used in the treatment of cancers and to combat harmful viruses, bacteria and parasites.

Nucleoside Mimetics book. Modified nucleosides are useful therapeutic agents being currently used as antitumor, antiviral, and antibiotic agents. Despite the fact that a significant variety of modified nucleosides displays potent and selective action against the mentioned diseases, the challenge still attracts full attention since most of them do not discriminate between normal and tumor cell and in viral.

from book Synthesis and Characterization of Glycosides 2nd Edition (pp) Nucleoside Mimetics. Chapter June 9 rows  Nucleoside mimetics are the class of small molecule drugs with antitumor, antiviral, and. Nucleoside dicarboxylates were another type of proposed mimetics of NDPs whose synthesis and bioactivity studies were reported.

78 The protected 5′-enofuranosyluracil derivative 32 was the key precursor for the introduction of a dicarboxylate moiety in the nucleoside (Scheme 7).

The development of nucleoside and nucleotide inhibitors of the HCV RNA-dependent RNA polymerase (RdRp) Nucleoside Mimetics book continued since with no less than 16 agents entering clinical development (), 36 In the last several years, a number of extensive reviews covering HCV polymerase inhibitors have appeared, 36 Recently, the uridine nucleotide prodrug sofosbuvir (SOF, 42) 37 became the first Cited by: 4.

Structure-based design of nucleoside-derived analogues as sulfotransferase inhibitors and PAPS mimetics based upon 2′-deoxyadenosine and using 2′-deoxy-PAP as a benchmark. The use of allyl groups as masked methyl esters was exploited in the synthesis of PAP-mimetics, and click chemistry was employed for the Nucleoside Mimetics book synthesis of a Author: Neil M.

Kershaw, Dominic P. Byrne, Hollie Parsons, Neil G. Nucleoside Mimetics book Berry, David G. Fernig, Patrick A. Nucleoside Mimetics book Eyers.

Currently, unsaturated nucleoside mimetics, such as stavudine, abacavir and entecavir have been approved for the treatment of Nucleoside Mimetics book infections, while elvucitabine and β -L-2´ -F-d4C are in clinical by: 7.

Nucleoside Mimetics. , DOI: /_4. Makoto Nomura, Tsutomu Sato, Masato Washinosu, Motoaki Tanaka, Tetsuji Asao, Satoshi Shuto, Akira Matsuda. Nucleosides and nucleotides.

Part Practical large-scale synthesis of 1-(3-C-ethynyl-β-d-ribo-pentofuranosyl)cytosine (ECyd), a potent antitumor nucleoside. Nucleoside Mimetics book book provides an overview with insights in to nucleosides mimetics.

[It] will enhance research and academic library collections on biochemical and medicinal chemistry subjects." - E-Streams, Vol. 4, No. 10, Oct. Read more. Synthesis and Characterization of Glycosides. Authors: Brito-Arias, Marco Nucleoside Mimetics. *immediately available upon purchase as print book shipments may be delayed due to the COVID crisis.

ebook access is temporary and does not include ownership of the ebook. Only valid for books with an ebook version. For four decades, nucleoside mimetics have attracted considerable attention in synthetic chemistry, owing to their antiviral activities against HIV, HBV, HSV, and others.

This chapter presents a few highlights of the fascinating world of nucleoside by: 8. Books shelved as memetics: Virus of the Mind: The New Science of the Meme by Richard Brodie, The Meme Machine by Susan Blackmore, The Selfish Gene by Ric.

This book contains the best known approaches for preparing the main types of glycosides in a short and comprehensive study. It also includes synthetic pathways of challenging glycosides known as antiviral or antineoplasic drugs, or synthetic substrates used for enzymatic detection including those used as substrates for detection of gene markers in plant s: 1.

The direct and chemoselective 3′-phosphoramidation, phosphorylation and acylation of nucleosides are described. Upon the discovery of a novel 3′-phosphorylamidation of therapeutic nucleoside analogues with DBU, we explored the mechanism of this rare selectivity through a combination of NMR spectroscopy and c.

Nucleoside Triphosphate and Their Analogs: Chemistry, Biotechnology, and Biological Applications discusses the potential of current applications and future research into context with an in-depth analysis of the role anticancer and antiviral nucleoside analogs play in medical treatments, including antiretroviral therapy regimens (for the.

This book, based on a lecture course which is given to final year undergraduates at Liverpool, illustrates the main features of f-block chemistry, along with some of the important applications, outlining the spectroscopic techniques which are commonly applied to complexes of the f-block elements.

Nucleoside mimetics: their chemistry and biological properties. [Claire Simons] Home. WorldCat Home About WorldCat Help. Search. Search for Library Items Search for Lists Search for Contacts Search for a Library. Create Book\/a>, schema:MediaObject\/a>, schema:CreativeWork\/a>.

Book. Advanced Search. Toggle navigation. in the management of several viral infections, including HSV, HIV, HBV, HCV and HCMV infections. Currently, unsaturated nucleoside mimetics, such as stavudine, abacavir and entecavir have been approved for the treatment of viral infections, while elvucitabine and β-L-2β- F-d4C are in clinical.

Nucleoside analogues are nucleosides which contain a nucleic acid analogue and a sugar. Nucleotide analogs are nucleotides which contain a nucleic acid analogue, a sugar, and a phosphate groups with one to three phosphates.

Nucleoside and nucleotide analogues can be used in therapeutic drugs, include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside Mimetics provides an introduction to the chemistry of nucleoside mimetics, which combines carbohydrate, heterocyclic and asymmetric synthesis.

The book gives a comprehensive introduction to nucleosides and coverage of the various classes. Synthesis and Characterization of Glycosides. Authors: Brito-Arias, Marco The organization of the book provides a ready resource for researchers seeking information.

Indeed, the references to published synthetic methodology or analytical data included at the end of each chapter will be useful for researchers seeking additional information.

Chapter 4 Nucleoside Mimetics Altmetric Badge. Chapter 5 C-Glycosides Altmetric Badge. Chapter 6 Glycoconjugates Altmetric Badge. Altmetric Badge. Chapter 10 Mass Spectrometry of Glycosides Overall attention for this book and its chapters Altmetric Badge.

Mentioned by syllabi 1 institution with syllabi facebook 1 Facebook page. Readers on. In addition to our recent report on the potent anti-varicella-zoster virus (VZV) activity of some unusual bicyclic furopyrimidine nucleosides bearing long alkyl side chains, we herein report the further significant enhancement of the antiviral potency by inclusion of a phenyl group in the side chain of these compounds.

The target structures were prepared by the Pd-catalyzed coupling of a Cited by:   Recently, however, new emissive and responsive nucleoside mimetics based on thieno[3,4-d]pyrimidine, which maintain normal Watson-Crick base pairing, have been described for all four RNA nucleosides, 19–21 that either are isosteric with the nucleoside being mimicked [th Guanosine (th G, Figure 1a) or th Adenosine] or have the effect of Cited by: Nucleoside Mimetics: Their Chemistry and Biological Properties Price Claire Simons Advanced Chemistry Texts Volume 3 ; Transition Metal Carbonyl Cluster Chemistry Paul J Dyson and J.

Scott McIndoe Advanced Chemistry Texts Volume 4, ; Chemistry of the f-block elements Helen C Aspinall Advanced Chemistry Texts Volume 5, Molecules, an international, peer-reviewed Open Access journal.

Journals. Interests: Nucleoside modification via metal-catalyzed and uncatalyzed processes, synthesis of novel nucleoside structures, has been designed as mimetics of the pyrimidine nucleobases. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds.

Throughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used. Biological function. While a nucleoside is a nucleobase linked to a sugar, a nucleotide is composed of a nucleoside and one or more phosphate groups.

Thus, nucleosides can be phosphorylated by specific kinases in the cell on the sugar's primary alcohol group (-CH 2-OH) to produce tides are the molecular building-blocks of DNA and RNA.

Memetics is the study of information and culture based on an analogy with Darwinian ents describe memetics as an approach to evolutionary models of cultural information cs describes how an idea can propagate successfully, but doesn't necessarily imply a concept is factual.

Critics contend the theory is "untested, unsupported or incorrect". Overall, the data revealed that PMEO- DAPym represents the prototype compound of a novel class of pyrimidine acyclic nucleoside phosphonates that are recognized as a purine nucleotide and should form the rational basis for the design and development of novel purine nucleo(s)(t)ide mimetics as potential antiviral or antimetabolic by: Novel N-methoxymethylated (MOM) pyrimidine () and pyrimidine-2,4-diones () nucleoside mimetics in which an isobutyl side-chain is attached at the C-6 position of the pyrimidine moiety were synthesized.

Synthetic methods via O-persilylated or N-anionic uracil derivatives have been evaluated for the synthesis of N and/or NMOM pyrimidine derivatives with C-6 acyclic by: 5. Combinatorial synthesis techniques for access to diverse sets of nucleoside mimetics Combinatorial chemistry today allows the systematic preparation and screening of a huge number of compounds in libraries of different size, which in turn allow the identification of individual compounds highly active in a few days or weeks.

Molette Laboratory for Drug Discovery, Department of Chemistry and Biochemistry, Auburn University, Auburn, ALUSA Fax: +1() Email: [email protected]: Wei Ye, Stewart W. Schneller. A pair of new anticancer nucleosides based on 1,2,4-triazole nucleosides and 1-((2-hydroxyethoxy) methyl)(phenylthio)-1H-1,2,4-triazolecarboxamide have been synthesized, and have given the corresponding products in excellent yields.

Its structures and conformations were confirmed by single crystal X-ray : Yulong Lei, Dehua Zhang, Yang Liu, Guanghui Tian, Hongguang Ge. New xylofuranosyl and glucopyranosyl nucleoside phosphoramidates were synthesized as potential mimetics of nucleoside 5′-monophosphates.

Their access involved N -glycosylation of uracil and 2-acetamidochloropurine with 5′/6′-azido-1,2-di- O -acetyl glycosyl donors and subsequent Staudinger-phosphite reaction of the resulting azido.

Read 2 answers by scientists to the question asked by Evanguedes Kalapothakis on   The Experimental Therapy Charlie Gard's Parents Are Fighting For, Explained Nucleoside bypass therapy is highly experimental and has never been used on .Peptide nucleic ebook (PNA) Peptide nucleic acid (PNA) is a nucleic acid analogue in which the normal phosphate linkage found in DNA and RNA is replaced by an neutral peptide-like N-(2-aminoethyl)glycine backbone (Figure 1, Figure 2).